Plates-formes technologiques partenaires
| THEMATIQUES | LOCALISATIONS |
| Imagerie et cytométrie de flux |
Gif sur Yvette ; Châtenay-Malabry ; Clamart ; |
| Criblage haut débit et pharmacologie moléculaire | Gif sur Yvette ; Châtenay-Malabry ; Saclay ; Villejuif |
| "omics" | Gif sur Yvette ; Châtenay-Malabry |
| Animalerie et exploration fonctionnelle | Châtenay-Malabry ; Clamart ; Villejuif |
| Support analytique | Saclay, Gif sur Yvette ; Châtenay-Malabry ; Orsay ; Thiais |
| Divers | Villejuif ; Saclay |
Regroupement de plateformes:
ICMMO Institut de Chimie Moléculaire et des Matériaux d'Orsay - Orsay
Poster Web
IPSIT Institut Paris-Sud d'Innovation Thérapeutique - Châtenay-Malabry ; Clamart
Poster Fiche Web
IMAGIF - Gif sur Yvette
Web
Gustave Roussy Gustave Roussy - Villejuif
Web
Imagerie et Cytométrie de Flux
Plateforme Imagerie Cellulaire (MIPSIT) IPSIT Châtenay-Malabry
Poster Fiche Web
Plateforme Immuno-monitorage (PLAIMMO) IPSIT Clamart
Poster Fiche Web
Plateforme d'imagerie cellulaire de l'UMR-S 999 Le Plessis Robinson
Poster Web
Plateau Technique d'Imagerie Cellulaire et Tissulaire de l'Institut Biomédical de Bicêtre (I2B) Le Kremlin Bicêtre
Poster Web
Pôle de biologie cellulaire IMAGIF Gif sur Yvette
poster Web
Plateforme d'Imagerie et Cytometrie (PFIC) Gustave Roussy Villejuif
Poster Web
Criblage haut débit et pharmacologie moléculaire
Plateforme CIBLOT IPSIT Châtenay-Malabry
Poster Fiche Web
Plateforme Interactions Moléculaires IPSIT Châtenay-Malabry
Poster Fiche Web
Ciblothèque Cellulaire IMAGIF Gif sur Yvette
Poster Web
Plateforme de Clonage et Mutagénèse– Plateforme de Cristallisation IMAGIF Gif sur Yvette
Poster Web 1
Plateforme de Biophysique IMAGIF Gif sur Yvette
Poster Web
Plateforme de Criblage de Thermostabilité des Protéines par Fluorescence (CTPF) IMAGIF Gif sur Yvette
Poster Web
Plateforme de Chimie Combinatoire et de Criblages à Haut Débit Saclay CEA/SCBM Saclay
Poster Web
Laboratoire de Biologie Structurale et Radiobiologie – Biologie Structurale Intégrative Saclay CEA Saclay
Web
Plateforme de Génotypage à haut débit / Mass Array Hôpital Paul Brousse Villejuif
Poster Fiche
"omics"
Plateforme de Transcriptomique et Protéomique (Trans-Prot) IPSIT Châtenay-Malabry
Poster Fiche Web
Service d'Identification et de Caractérisation des Protéines par Spectrométrie de Masse (SICaPS) IMAGIF Gif sur Yvette
Poster Web
Plateforme de PCR Quantitative Haut Débit (QPCR) IMAGIF Gif sur Yvette
Poster Web
Plateforme de Séquençage Haut-Débit IMAGIF Gif sur Yvette
Poster Web
Animalerie et Exploration Fonctionnelle
Plateforme Animalerie et Exploration Fonctionnelle (AnimEx) IPSIT Châtenay-Malabry
Poster Fiche Web
Plateforme d'Histologie Souris Immunopathologie IPSIT Clamart
Poster Fiche Web
Plateforme Evaluation Préclinique Gustave Roussy Villejuif
Poster Web
Support analytique
Service d'Analyse des Médicaments et Métabolites (SAMM) IPSIT Châtenay-Malabry
Poster Fiche Web
Plateforme de RMN IMAGIF Gif sur Yvette
Poster Fiche Web
Plateforme Spectrométrie de masse IMAGIF Gif sur Yvette
Web
Laboratoire d'Extraction de Principes Actifs IMAGIF Gif sur Yvette
Web
Plateforme de Microcalorimétrie IMAGIF Gif sur Yvette
Poster Web
Plateforme SMArtMS CEA Saclay
Poster Web
Plateforme RMN ICMMO Orsay
Web
Microscopies Electroniques à Balayage et en Transmission (MEB/MET) ICMMO Orsay
Poster Web
Plateforme Chromatographie Analytique et semi Préparative ICMPE Thiais
Poster Fiche Web
Divers
Plateforme Cellules Souches UPSud/UMR-S 935 Villejuif
Web
Plateforme L3 Hôpital Paul Brousse Villejuif
Poster
Laboratories, partners and teams
| # | Partenaire / Laboratoire | Unité | Localité |
| 1 | COMUE Université Paris-Saclay President : Sylvie Retailleau |
Partner Coordinator |
Saint Aubin |
| 2 | Signaling and Cardiac Pathophysiology Director : Ana Maria Gomez |
INSERM UMR-S 1180 (ex 769) 3 teams |
Faculté de Pharmacie, Université Paris-Sud Chatenay-Malabry |
| 3 | Cytokines, Chemokines et Immunopathology Director : Françoise Bachelerie |
INSERM UMR-S 996 4 teams |
Faculté de Pharmacie, Université Paris-Sud Chatenay-Malabry |
| 4 | Service of Immuno-Virology Director : Roger Legrand |
INSERM UMR-S 1184 (ex 1012) 1 team |
Faculté de Médecine, Université Paris-Sud Le Kremlin Bicêtre |
| 5 | Endogenous retroviruses and retroid element in higher eucaryotes Director : Thierry Heidmann |
CNRS UMR 9196 (ex 8122) 1 team |
Gustave Roussy Villejuif |
| 6 | Pulmonary Hypertension : Pathophysiology and Novel Therapies Director : Marc Humbert |
INSERM UMR-S 999 2 teams |
Hôpital Marie Lannelongue, Faculté de Médecine, Université Paris-Sud Le Plessis-Robinson |
| 7 | Structure, Dynamics, Function and Expression of braod-spectrum Beta-lactamases Director : Thierry Naas |
EA 7361 (ex UMR-S 914) 1 team |
CHU de Bicêtre Faculté de Médecine Université Paris-Sud Le Kremlin Bicêtre |
| 8 | Radiosensitivity and human radiocarcinogenesis Director : Eric Deutsch |
INSERM UMR-S 1030 2 teams |
Gustave Roussy Faculté de Médecine, Université Paris-Sud Villejuif |
| 9 | Identification of molecular predictors for treatment efficacy Director : Fabrice André |
INSERM UMR-S 981 1 team |
Gustave Roussy Faculté de Médecine, Université Paris-Sud Villejuif |
| 10 | Laboratory of Biology and Applied Pharmacology Director : Malcolm Buckle |
CNRS UMR 8113 2 teams |
Ecole Normale Supérieure de Cachan Cachan |
| 11 | Molecular engineering of proteins (SIMOPRO) Director : Vincent Dive |
CEA DRF Joliot SIMOPRO 5 teams |
CEA DRF SIMOPRO Frédéric Joliot Life Sciences Institute Saclay |
| 12 | Molecular labelling and bioorganic chemistry (SCBM) Director : Frédéric Taran |
CEA DRF Joliot SCBM 4 teams |
CEA DRF SCBM Frédéric Joliot Life Sciences Institute Saclay |
| 13 | Institut de Chimie des Substances Naturelles (ICSN) Director : Angela Marinetti |
CNRS UPR 2301 10 teams |
Gif sur Yvette |
| 14 | Institut de Chimie Moléculaire et des matériaux d'Orsay (ICMMO) Director : David Aitken |
CNRS UMR 8182 2 teams |
Université Paris Sud Orsay |
| 15 | Biomolécules: conception isolement et synthèse (BioCIS) Director : Bruno Figadere |
CNRS UMR-8076 4 teams |
Faculté de Pharmacie, Université Paris-Sud Chatenay-Malabry |
| 16 | Institut Galien Paris-Sud Director : Elias Fattal |
CNRS UMR 8612 5 teams |
Faculté de Pharmacie, Université Paris-Sud Chatenay-Malabry |
| 17 | Service of Pharmacology and Immunoanalysis Director : Christophe Junot |
CEA DRF SPI Frédéric Joliot Life Sciences Institute Saclay |
Partner 2
Signaling and Cardiac Pathophysiology – INSERM UMR-S 1180 (ex 769)
Director : Ana Maria Gomez
- Energetic Signalling and Cardiac and Muscular Pathophysiology
(Anne Garnier-Fagart & Vladimir Veksler) - Cyclic Nucleotide Signaling and Cardiac and Vascular Pathophysiology
(Rodolphe Fischmeister & Grégoire Vandecasteele) - Calcium Signaling and Cardiac Pathophysiology
(Ana Maria Gomez & Jean-Pierre Benitah)
Partner 3
Cytokines, Chemokines and Immunopathology – INSERM UMR-S 996
Director : Françoise Bachelerie
- Dendritic cells, Mast cells and Immune Tolerance
(Françoise Bachelerie) - Mechanism of innate cell signaling in immunotoxicology and immunopharmacology
(Marc Pallardy) - The chemokine SDF-1/CXCL12 and its receptors in immunopathology
(Karl Balabanian) - Inflammation and cell recruitmentin obesity- and alcohol-induced liver diseases
(Gabriel Perlemuter)
Partner 4
Service of immuno-virology - INSERM UMR-S 1184
Director : Roger Legrand (Correspondant : Xavier Mariette)
Partner 5
Endogenous retroviruses and retroid element in higher eucaryotes - CNRS UMR 9196 (ex 8122)
Director : Thierry Heidmann
Partner 6
Pulmonary Hypertension : Pathophysiology and Novel Therapies - INSERM UMR-S 999
National Refferal Centre for Severe Pulmonary Hypertension
Director : Marc Humbert
- Physiopathology and Immunopathology of Pulmonary Hypertension
(Marc Humbert & Sylvia Cohen-Kaminsky) - Novel clinical approachs of pulmonary hypertension
(Olivier Sitbon)
Partner 7
Structure, Dynamics, Function and Expression of braod-spectrum Beta-lactamases - UPSUD EA 7361 (ex UMR-S 914)
Director : Thierry Naas
Partner 8
Radiosensitivity and human radiocarcinogenesis – INSERM UMR-S 1030
Director : Eric Deutsch
Partner 9
Biomarkers and new molecular strategies in oncology - INSERM UMR-S 981
Director : Fabrice Andre
Partner 10
Laboratory of Biology and Applied Pharmacology - CNRS Ecole Normale Supérieur Paris-Saclay UMR 8113
Director : Malcolm Buckle (Coordinator : François Dautry)
- Molecular Oncology and Pharmacology
(Jean-Marc Ricort) - Structural biology of small GTPases
(Jacqueline Cherfils)
Partner 11
Molecular engineering of proteins (SIMOPRO) – CEA DRF - Frédéric Joliot Life Sciences Institute
Director : Vincent Dive
- Function of zinc-metalloproteases
(Vincent Dive) - Immunochemistry of the cellular immune response
(Bernard Maillère) - Toxin-Membrane Interactions
(Daniel Gillet) - Enzymology and non-ribosomal biosynthesis
(Muriel Gondry) - Toxins, receptors and channels
(Denis Servent)
Partner 12
Molecular labelling and bioorganic chemistry (SCBM) – CEA DRF - Frédéric Joliot Life Sciences Institute
Director : Frédéric Taran
- Tritium and Self Assembly
(Bernard Rousseau) - Nanosciences
(Eric Doris) - Molecular modelling & engineering of Tc-containing peptide/proteins
(Philippe Cuniasse & Christophe Dugave) - Iodine Transport and Metabolism
(Yves Ambroise) - Combinatorial chemistry and high throughput screening
(Jean-Christophe Cintrat)
Partner 13
Institut de Chimie des Substances Naturelles (ICSN) – CNRS UPR 2301
Director : Angela Marinetti (Coordinator : Eric Guittet)
- Chemistry of bioactive marine metabolites
(Ali Al-Mourabit) - Synthesis and Methodology Applied to Research in Therapeutics (SMART)
(Robert Dodd) - Synthesis and biological evaluation of protein prenylation pathway inhibitors
(Joëlle Dubois) - Synthesis of natural products of biological interest and medicinal chemistry
(Catherine Guillou) - ICSN-Pilot-Unit
(Jamal Ouazzani) - Natural Products-Plants : Isolation, Synthesis
(Fanny Roussi) - Natural substances and biodiversity
(Véronique Eparvier) - Mass Spectrometry group
(Alain Brunelle) - Laboratory of Structural Biology and Chemistry
(Eric Guittet) - Molecular Modelling and Structural Crystallography Team
(Bogdan Iorga)
Partner 14
Institut de Chimie Moléculaire et des Matériaux d'Orsay (ICMMO) – CNRS UMR 8182
Director : David Aitken (Coordinator : David Bonnaffé)
Molecular and Macromolecular Gycochemistry (G2M)
(David Bonnaffé)
Bioorganic and Bioinorganic Chemistry (LCBB)
(Laurent Salmon)
Partner 15
Laboratoire Biomolécules : conception, isolement et synthèse (BioCIS) – CNRS UMR 8076
Director : Bruno Figadère
- Chimie des Substances Naturelles - Pharmacognosie
(Bruno Figadère & Erwan Poupon) - Chimiothérapie antiparasitaire
(Philippe Loiseau) - Molécules Fluorées et Chimie Médicinale
(Sandrine Ongeri & Benoit Crousse) - Conception et Synthèse de Molécules d’Intérêt Thérapeutique
(Jean-Daniel Brion & Mouad Alami)
Partner 16
Institut Galien Paris-Sud - CNRS UMR 8612
Director : Elias Fattal
- Targeting and Delivery of Poorly Stable Active Drugs
(Elias Fattal) - Chemistry and Physic of multiphase systems
(Sylviane Lesieur) - Physical Pharmacy
(Florence Agnely) - Improvement of the transport of biologically active drugs
(Gilles Ponchel) - Surface Physical Chemistry
(Véronique Rosilio)
Partner 17
Service of Pharmacology and Immunoanalysis(SPI)- CEA DRF - Frédéric Joliot Life Sciences Institute
Director : Christophe Junot
- Drug metabolism research laboratory
(François Fenaille) - Immunoanalysis studies and research laboratory
(Stéphanie Simon)
Topics
| CANCER | HEART LUNG |
IMMUNOLOGY INFECTIOLOGY |
|
| TARGETS | 5 teams | 15 teams |
9 teams |
| RESISTANCE | 7 teams |
4 teams |
9 teams |
| DELIVERY | 7 teams |
5 teams |
8 teams |
The goal of LERMIT is thus to foster interdisciplinary research at the interface between chemistry, physico-chemistry and biology. Organizing the research around this main objective was not an easy task and required heavy brainstorming and stimulating discussions. As a result, we decided to organise the research within LERMIT around three main topics.
The first topic – TARGETS - aims at identifying and validating new therapeutic targets in the three classes of diseases listed above. This includes discovery of molecular mechanisms, proof of concept in cellular and animal models, screening of chemical libraries, validation and chemical optimization of the hits, preliminary ADMET and drugability tests, molecular modelling, evaluation of the lead molecules in animal models, etc. Three specific projects are proposed below to find new drugs to fight against 1) cardiovascular diseases (T1), 2) inflammation and immune deficiency (T2) and 3) cancer (T3).
The second topic – RESISTANCE - aims at identifying new strategies to get around the reduction in effectiveness of a drug in curing a disease. This concerns obviously the resistance to antimicrobial and anti-cancer drugs, but also more recently the resistance to immunotherapies. Resistance involves molecular mechanisms, such as mutation of the target enzyme or its relocation. Identifying these mechanisms allows a predictive structural pharmacological approach and the design of new and more efficient drugs. Two specific projects are proposed, one is to fight the antibiotic-resistant Gram-negative bacteria (R1), and the other to overcome biotherapy treatment failure in patients with rheumatoid arthritis (R2).
The third topic – DELIVERY – aims at designing new delivery systems, mainly nano and microtechnologies, to improve i) drug delivery to the right target and avoiding broad distribution that induce toxicity, ii) protection against degradation, and iii) drug transport across biological barriers. Because of a strong expertise within LERMIT in the field of cardiovascular diseases, we propose an innovative and ambitious interdisciplinary project to target the cardiovascular sphere and the pulmonary vasculature (D1).
